A 75-year-old Caucasian woman was seen at a nearby community clinic for a raised lesion on her right Show more A 75-year-old Caucasian woman was seen at a nearby community clinic for a raised lesion on her right thigh. She had noticed that the pale tan to light gray color of the lesion was changing. Examination by the referring experienced dermatologist showed a rough and coarsely granular oval lesion with a slightly irregular border measuring 1.7 x 0.9 cm. Clinically this lesion was thought to resemble an irritated seborrheic keratosis and was biopsied because of its size a slight variability in color and a clinical history of color change. The biopsy requisition diagnosis read Irritated Seborrheic Keratosis. Histopathologic examination of a deep-shave biopsy showed the low-power silhouette of a seborrheic keratosis including squamous papilloma-like features and delicate laminated pseudocysts of horn. The final diagnosis was malignant melanoma superficial spreading type Clarks level III Breslow 1.44 mm probable vertical growth phase and simulating a seborrheic keratosis. Outline the diagnosis of skin cancer in this case and compare and contrast the nature of basal cell carcinoma squamous cell carcinoma and malignant melanoma. Show less
