A 75-year-old Caucasian woman was seen at a nearby community clinic for a raised lesion on her right Show more A 75-year-old Caucasian woman was seen at a nearby community clinic for a raised lesion on her right thigh. She had noticed that the pale tan to light gray color of the lesion was changing. Examination by the referring experienced dermatologist showed a rough and coarsely granular oval lesion with a slightly irregular border measuring 1.7 x 0.9 cm. Clinically this lesion was thought to resemble an irritated seborrheic keratosis and was biopsied because of its size a slight variability in color and a clinical history of color change. The biopsy requisition diagnosis read Irritated Seborrheic Keratosis. Histopathologic examination of a deep-shave biopsy showed the low-power silhouette of a seborrheic keratosis including squamous papilloma-like features and delicate laminated pseudocysts of horn. The final diagnosis was malignant melanoma superficial spreading type Clarks level III Breslow 1.44 mm probable vertical growth phase and simulating a seborrheic keratosis. Discussion Question Outline the diagnosis of skin cancer in this case and compare and contrast the nature of basal cell carcinoma squamous cell carcinoma and malignant melanoma. Show less
